A British historian, an Italian archaeologist, and an American preschool teacher have never met, yet they have a strong pandemic tie.
The three ladies are credited for defining, naming, and bringing long COVID into the public’s notice in early 2020, despite having strikingly similar symptoms.
Rachel Pope of Liverpool turned to Twitter in late March 2020 to discuss her perplexing symptoms caused by a coronavirus infection, which were then nameless. In May of that year, Elisa Perego of Italy used the phrase “long COVID” for the first time in a tweet. Amy Watson in Portland, Oregon, was inspired to name her Facebook support group “long hauler” after the trucker cap she was wearing, and “long hauler” quickly became part of the epidemic vernacular.
Scientists are still attempting to understand out why some people develop lengthy COVID and why a tiny percentage, like the three ladies, have long-term symptoms nearly three years after the pandemic.
Millions of people throughout the world have long had COVID, reporting a variety of symptoms such as weariness, lung issues, brain fog, and other neurological symptoms. Although evidence shows that most recover significantly within a year, current data reveal that it has linked to more than 3,500 fatalities in the United States.
Here is some of the most recent evidence:
ARE WOMEN AT A HIGHER RISK?
According to several studies and anecdotal data, women are more prone than males to acquire lengthy COVID.
There might be biological causes for this.
According to Sabra Klein, a Johns Hopkins researcher who researches immunity, women’s immune systems often produce higher responses to viruses, bacteria, parasites, and other pathogens.
Women are also far more prone than males to suffer from autoimmune illnesses, in which the body incorrectly assaults its own healthy cells. Long COVID, according to some experts, might be the result of an autoimmune reaction produced by the virus.
Women’s bodies have greater fat tissue, and new study reveals that the coronavirus may lurk in fat following infection. Scientists are also investigating if changing hormone levels in women may raise the dangers.
Another point to consider: women are more likely than males to seek medical attention and are typically more sensitive to changes in their bodies, according to Klein.
“I don’t believe we should dismiss it,” she stated. Klein believes that both biology and behavior are at work.
It’s no surprise that three women were instrumental in shedding light on lengthy COVID.
Pope, 46, began documenting her symptoms in March 2020: flu-like symptoms, followed by problems with her lungs, heart, and joints. After a month, she began to have “OK” days, but the symptoms lingered.
She and a few other sick coworkers connected with Perego on Twitter. “We kind of began gathering together because that was basically the only location where we could do that,” Pope explained. “In 2020, we’d joke about getting together for Christmas and throwing a party,” Pope added. “Obviously, things progressed, and I believe we stopped joking.”
Watson founded her virtual long truckers club in April of that year. The others quickly picked up on the nickname and adopted it.
THE MONO VIRUS
Several studies show that the common Epstein-Barr virus may be involved in some cases of protracted COVID.
According to Dr. Timothy Henrich, a virus expert at the University of California, San Francisco, inflammation generated by coronavirus infection can activate herpes viruses, which persist in the body after producing an acute illness.
The Epstein-Barr virus is one of the most prevalent herpes viruses, infecting an estimated 90% of the US population. The virus can induce mononucleosis or symptoms that are mistaken for the common cold.
Henrich is one of the researchers that discovered immunological markers indicating Epstein-Barr reactivation in the blood of long-term COVID patients, particularly those who experience tiredness.
These indicators are not present in all long-term COVID patients. However, it’s plausible that Epstein-Barr is producing symptoms in people who have it, though additional research is needed.
Some researchers think Epstein-Barr causes chronic fatigue syndrome, a disorder that has many parallels to lengthy COVID but is similarly unconfirmed.
OBESITY
Obesity is a risk factor for severe COVID-19 infections, and researchers are investigating why.
Researchers from Stanford University are among those who have discovered evidence that the coronavirus may infect fat cells. In a recent investigation, scientists discovered the virus and symptoms of inflammation in adipose tissue from COVID victims.
The virus can multiply in adipose tissue, according to laboratory testing. This suggests that adipose tissue might act as a “reservoir,” potentially fueling extended COVID.
Could adipose tissue removal be used to cure or prevent certain cases of extended COVID? The idea is intriguing, but the research is preliminary, according to Dr. Catherine Blish, a Stanford infectious diseases professor and senior author of the paper.
Researchers at the University of Texas Southwestern Medical Center are investigating leptin, a hormone generated by fat cells that can alter the immune system and cause inflammation.
They intend to investigate if injections of a synthetic antibody might lower leptin levels, and thereby inflammation caused by coronavirus infections or protracted COVID.
“We have a sound scientific foundation and preliminary evidence to demonstrate that we could be on the right road,” Dr. Philipp Scherer remarked.
DURATION
Based on data from earlier in the epidemic, it is expected that around 30% of patients infected with the coronavirus would acquire protracted COVID.
Most people who have lasting, recurring, or new symptoms after an illness will recover in three months or less. According to a recent research published in the Journal of the American Medical Association, around 15% of individuals who experience symptoms at three months will continue to have them for at least nine months.
Identifying who is at risk for long-term symptoms is a “difficult subject,” according to Dr. Lawrence Purpura, an infectious disease expert at Columbia University.
Long COVID appears to be more common in persons with severe illnesses, while it can equally afflict those with moderate infections. Those whose infections cause serious lung damage, including scarring, may have shortness of breath, coughing, or exhaustion for up to a year. A smaller percentage of individuals with mild initial COVID-19 infections may develop neurologic symptoms such as persistent weariness and brain fog for more than a year, according to Purpura.
“The vast majority of people will recover,” he stated. “It’s critical that folks understand that.”
It’s a little consolation for the three ladies who pioneered the recognition of extended COVID.
Perego, 44, experienced heart, lung, and neurological issues and is still very ill.
She recognizes that scientists have learnt a lot in a short period of time, but she believes that “there is a gap” between long-term COVID research and medical care.
“We must integrate scientific knowledge into improved treatment and policy,” she stated.
Watson, who is about to turn 50, claims she has “never had any type of recovery.” She has suffered from severe headaches, as well as stomach, neurological, and foot issues. She recently acquired severe anemia.
She wants the medical profession will take a more systematic approach to managing lengthy COVID. Doctors say it’s challenging since they don’t know what’s causing it.
“I just want my life back,” Watson said, “and it doesn’t appear like that’s going to happen.”
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